Improvements in Treating Crows Feet


January 17, 2012


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According to Medical New Today, a study by Kenneth C.Y. Yu, M.D., from The Maas Clinic, San Francisco, and the University of California San Francisco, demonstrates the efficiency of two botulinum neuromodulators in improving the appearance of crow's feet, also known as lateral orbital rhytids.

77 women and 13 men with moderate-to-severe crow’s feet participated in the study. Patients received an injection of onabotulinumtoxinA, 10 U, on one side of their face and abobotulinumtoxinA, 30 U, on the other side of their face.

The researchers took photos of participants prior to treatment and on days two, four and six following the injections.

The report states: "AbobotulinumtoxinA and onabotulinumtoxinA demonstrated statistically significant change from baseline at day two in the treatment of lateral orbital rhytids at maximal contraction and rest when evaluated independently by investigator and participant.

By day four, the greater improvement achieved with abobotulinumtoxinA reached statistical significance and remained superior at day six.”

No side effects or complications were observed during the investigation with either product.

Botulinum toxin is a potent neuromodulator produced by the bacterium Clostridium botulinum. It work by blocking the action of acetylcholine (a neurotransmitter), and thus producing a state of functional denervation.

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